Fyn-mediated phosphorylation of Menin disrupts telomere maintenance in stem cells

Telomeres protect chromosome ends and determine the replication potential of dividing cells. The canonical telomere sequence TTAGGG is synthesized by telomerase holoenzyme, which maintains telomere length in proliferative stem cells. Although the core components of telomerase are well-defined, mecha...

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Detalles Bibliográficos
Autores principales: Paul, Souren, McCourt, Preston M., Le, Le Thi My, Ryu, Joohyun, Czaja, Wioletta, Bode, Ann M., Contreras-Galindo, Rafael, Dong, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592958/
https://www.ncbi.nlm.nih.gov/pubmed/37873235
http://dx.doi.org/10.1101/2023.10.04.560876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592958/
https://www.ncbi.nlm.nih.gov/pubmed/37873235
http://dx.doi.org/10.1101/2023.10.04.560876

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