Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain

Intron branch point (BP) recognition by the U2 snRNP is a critical step of splicing, vulnerable to recurrent cancer mutations and bacterial natural product inhibitors. The BP binds a conserved pocket in the SF3B1 (human) or Hsh155 (yeast) U2 snRNP protein. Amino acids that line this pocket affect bi...

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Detalles Bibliográficos
Autores principales: Hunter, Oarteze, Talkish, Jason, Quick-Cleveland, Jen, Igel, Haller, Tan, Asako, Kuersten, Scott, Katzman, Sol, Donohue, John Paul, Jurica, Melissa, Ares, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592967/
https://www.ncbi.nlm.nih.gov/pubmed/37873484
http://dx.doi.org/10.1101/2023.10.05.560965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592967/
https://www.ncbi.nlm.nih.gov/pubmed/37873484
http://dx.doi.org/10.1101/2023.10.05.560965

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