The G1/S transition is promoted by Rb degradation via the E3 ligase UBR5

Mammalian cells make the decision to divide at the G1/S transition in response to diverse signals impinging on the retinoblastoma protein Rb, a cell cycle inhibitor and tumor suppressor. Rb is inhibited by two parallel pathways. In the canonical pathway, cyclin D-Cdk4/6 kinase complexes phosphorylat...

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Detalles Bibliográficos
Autores principales: Zhang, Shuyuan, Valenzuela, Lucas Fuentes, Zatulovskiy, Evgeny, Skotheim, Jan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592979/
https://www.ncbi.nlm.nih.gov/pubmed/37873473
http://dx.doi.org/10.1101/2023.10.03.560768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592979/
https://www.ncbi.nlm.nih.gov/pubmed/37873473
http://dx.doi.org/10.1101/2023.10.03.560768

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