PepMLM: Target Sequence-Conditioned Generation of Peptide Binders via Masked Language Modeling

Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity strategies, such as PROTACs and molecular glues, have thus gained attention as pharmacological alternatives, but still require small molecule doc...

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Detalles Bibliográficos
Autores principales: Chen, Tianlai, Pertsemlidis, Sarah, Watson, Rio, Kavirayuni, Venkata Srikar, Hsu, Ashley, Vure, Pranay, Pulugurta, Rishab, Vincoff, Sophia, Hong, Lauren, Wang, Tian, Yudistyra, Vivian, Haarer, Elena, Zhao, Lin, Chatterjee, Pranam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cornell University 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593082/
https://www.ncbi.nlm.nih.gov/pubmed/37873004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593082/
https://www.ncbi.nlm.nih.gov/pubmed/37873004

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