Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics

The selective inhibition of kinases from the diabetic kinome is known to promote the regeneration of beta cells and provide an opportunity for the curative treatment of diabetes. The effect can be achieved by carefully tailoring the selectivity of inhibitor toward a particular kinase, especially DYR...

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Detalles Bibliográficos
Autores principales: Pustelny, Katarzyna, Grygier, Przemyslaw, Barzowska, Agata, Pucelik, Barbara, Matsuda, Alex, Mrowiec, Krzysztof, Slugocka, Emilia, Popowicz, Grzegorz M., Dubin, Grzegorz, Czarna, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593742/
https://www.ncbi.nlm.nih.gov/pubmed/37872245
http://dx.doi.org/10.1038/s41598-023-44810-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593742/
https://www.ncbi.nlm.nih.gov/pubmed/37872245
http://dx.doi.org/10.1038/s41598-023-44810-3

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