Cargando…
Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics
The selective inhibition of kinases from the diabetic kinome is known to promote the regeneration of beta cells and provide an opportunity for the curative treatment of diabetes. The effect can be achieved by carefully tailoring the selectivity of inhibitor toward a particular kinase, especially DYR...
Autores principales: | Pustelny, Katarzyna, Grygier, Przemyslaw, Barzowska, Agata, Pucelik, Barbara, Matsuda, Alex, Mrowiec, Krzysztof, Slugocka, Emilia, Popowicz, Grzegorz M., Dubin, Grzegorz, Czarna, Anna |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593742/ https://www.ncbi.nlm.nih.gov/pubmed/37872245 http://dx.doi.org/10.1038/s41598-023-44810-3 |
Ejemplares similares
-
DYRK1A Kinase Inhibitors Promote β-Cell Survival and Insulin Homeostasis
por: Barzowska, Agata, et al.
Publicado: (2021) -
Silmitasertib
(CX-4945), a Clinically Used CK2-Kinase
Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases:
A Structural Perspective
por: Grygier, Przemyslaw, et al.
Publicado: (2023) -
DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets
por: Pucelik, Barbara, et al.
Publicado: (2023) -
Diabetic Kinome Inhibitors—A New Opportunity for β-Cells Restoration
por: Pucelik, Barbara, et al.
Publicado: (2021) -
Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)