Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach

Cancer has been viewed as one of the deadliest diseases worldwide. Among various types of cancer, breast cancer is the most common type of cancer in women. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a promising druggable target and is overexpressed in cancerous cells, like, breast cancer....

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Detalles Bibliográficos
Autores principales: Rana, Nisarg, Patel, Dhaval, Parmar, Meet, Mukherjee, Nandini, Jha, Prakash C., Manhas, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593809/
https://www.ncbi.nlm.nih.gov/pubmed/37872243
http://dx.doi.org/10.1038/s41598-023-45175-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593809/
https://www.ncbi.nlm.nih.gov/pubmed/37872243
http://dx.doi.org/10.1038/s41598-023-45175-3

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