Cargando…

Low Dopamine D2 Receptor Expression Drives Gene Networks Related to GABA, cAMP, Growth and Neuroinflammation in Striatal Indirect Pathway Neurons

BACKGROUND: A salient effect of addictive drugs is to hijack the dopamine reward system, an evolutionarily conserved driver of goal-directed behavior and learning. Reduced dopamine type 2 receptor availability in the striatum is an important pathophysiological mechanism for addiction that is both co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guerri, Lucia, Dobbs, Lauren K., da Silva e Silva, Daniel A., Meyers, Allen, Ge, Aaron, Lecaj, Lea, Djakuduel, Caroline, Islek, Damien, Hipolito, Dionisio, Martinez, Abdiel Badillo, Shen, Pei-Hong, Marietta, Cheryl A., Garamszegi, Susanna P., Capobianco, Enrico, Jiang, Zhijie, Schwandt, Melanie, Mash, Deborah C., Alvarez, Veronica A., Goldman, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Archival Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593893/ https://www.ncbi.nlm.nih.gov/pubmed/37881572 http://dx.doi.org/10.1016/j.bpsgos.2022.08.010

Ejemplares similares

Dysfunction of cAMP–Protein Kinase A–Calcium Signaling Axis in Striatal Medium Spiny Neurons: A Role in Schizophrenia and Huntington’s Disease Neuropathology
por: Fjodorova, Marija, et al.
Publicado: (2022)

Acute Changes in Striatal Microstructure Predict the Development of Interferon-Alpha Induced Fatigue
por: Dowell, Nicholas G., et al.
Publicado: (2016)

Gpr88 Deletion Impacts Motivational Control Without Overt Disruptions to Striatal Dopamine
por: Spark, Daisy L., et al.
Publicado: (2022)

Increased Impulsivity Retards the Transition to Dorsolateral Striatal Dopamine Control of Cocaine Seeking
por: Murray, Jennifer E., et al.
Publicado: (2014)

The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study
por: McCutcheon, Robert A., et al.
Publicado: (2020)

A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal
por: Coffey, Kevin R., et al.
Publicado: (2021)

Aberrant Striatal Value Representation in Huntington's Disease Gene Carriers 25 Years Before Onset
por: Nair, Akshay, et al.
Publicado: (2021)

Inhibition of Nigrostriatal Dopamine Release by Striatal GABA(A) and GABA(B) Receptors
por: Lopes, Emanuel F., et al.
Publicado: (2019)

(R,S)-Ketamine Promotes Striatal Neurogenesis and Sensorimotor Recovery Through Improving Poststroke Depression–Mediated Decrease in Atrial Natriuretic Peptide
por: Zhang, Yujing, et al.
Publicado: (2021)

Hippocampal α5-GABA(A) Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area
por: Perez, Stephanie M., et al.
Publicado: (2022)

Dopamine Synthesis Capacity and GABA and Glutamate Levels Separate Antipsychotic-Naïve Patients With First-Episode Psychosis From Healthy Control Subjects in a Multimodal Prediction Model
por: Sigvard, Anne K., et al.
Publicado: (2022)

A role for GABA in the modulation of striatal and hippocampal systems under stress
por: Dolfen, Nina, et al.
Publicado: (2021)

Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents
por: Flores-Hernández, Jorge, et al.
Publicado: (2018)

Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models
por: Mews, Philipp, et al.
Publicado: (2023)

The role of ventral striatal cAMP signaling in stress-induced behaviors
por: Plattner, Florian, et al.
Publicado: (2015)

On the functional role of striatal and anterior cingulate GABA+ in stimulus‐response binding
por: Takacs, Adam, et al.
Publicado: (2021)

Divergent properties and independent regulation of striatal dopamine and GABA co-transmission
por: Zych, Sarah M., et al.
Publicado: (2022)

Dopaminergic neurons inhibit striatal output via non-canonical release of GABA
por: Tritsch, Nicolas X., et al.
Publicado: (2012)

Distinct roles of synaptic and extrasynaptic GABA(A)receptors in striatal inhibition dynamics
por: Luo, Ruixi, et al.
Publicado: (2013)

Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat
por: Lee, Kyung Jin, et al.
Publicado: (2017)

Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling
por: Muntean, Brian S., et al.
Publicado: (2019)

Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling
por: Roberts, Bradley M., et al.
Publicado: (2021)

Demonstrating Benefit-Risk Profiles of Novel Therapeutic Strategies in Kidney Transplantation: Opportunities and Challenges of Real-World Evidence
por: Helanterä, Ilkka, et al.
Publicado: (2022)

Urological Complications Associated With Pyeloureterostomy Without Ipsilateral Nephrectomy in Renal Transplant Recipients
por: Neto, Hernani M., et al.
Publicado: (2022)

Differential Alteration in Expression of Striatal GABA(A)R Subunits in Mouse Models of Huntington’s Disease
por: Du, Zhuowei, et al.
Publicado: (2017)

The early excitatory action of striatal cholinergic-GABAergic microcircuits conditions the subsequent GABA inhibitory shift
por: Lozovaya, Natalia, et al.
Publicado: (2023)

Association of Non-Pharmaceutical Interventions to Reduce the Spread of SARS-CoV-2 With Anxiety and Depressive Symptoms: A Multi-National Study of 43 Countries
por: Riehm, Kira E., et al.
Publicado: (2022)

Physical Examination of Potential Deceased Organ and Tissue Donors: An Overview of the European Landscape
por: Chandrasekar, Akila, et al.
Publicado: (2023)

COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis
por: Rangel, Érika B., et al.
Publicado: (2022)

Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release
por: van Rhijn, Jon-Ruben, et al.
Publicado: (2018)

High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk
por: Nurnberger, John I., et al.
Publicado: (2021)

Identification of Co-Expression Modules and Genes Associated With Tumor Progression in Oral Squamous Cell Carcinoma
por: Fang, Zhijie, et al.
Publicado: (2022)

Analysis of Diffusion Tensor Imaging Data From the UK Biobank Confirms Dosage Effect of 15q11.2 Copy Number Variation on White Matter and Shows Association With Cognition
por: Silva, Ana I., et al.
Publicado: (2021)

Role of Type I Interferon Signaling and Microglia in the Abnormal Long-term Potentiation and Object Place Recognition Deficits of Male Mice With a Mutation of the Tuberous Sclerosis 2 Gene
por: López-Aranda, Manuel F., et al.
Publicado: (2022)

ACE2 and TMPRSS2 SNPs as Determinants of Susceptibility to, and Severity of, a COVID-19 Infection
por: Abdelsattar, S., et al.
Publicado: (2022)

Mi-RNA-93 and Mi-RNA-152 in the Diagnosis of Type 2 Diabetes and Diabetic Retinopathy
por: Saleh, A. A., et al.
Publicado: (2022)

Intermittent Short-Duration Re-oxygenation Attenuates Cardiac Changes in Response to Hypoxia: Histological, Ultrastructural and Oxidant/Antioxidant Parameters
por: Shati, Ayed A., et al.
Publicado: (2022)

Isocitrate Dehydrogenase IDH1 and IDH2 Mutations in Human Cancer: Prognostic Implications for Gliomas
por: Murugan, A. K., et al.
Publicado: (2022)

Association of Vitamin D Gene Polymorphisms With HCV Infection Outcome
por: Neamatallah, M., et al.
Publicado: (2022)

Dermatopathology and the Diagnosis of Fungal Infections
por: Howell, S. A.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_56bhgq9o6ggdj2ffnogsveriu9