Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L

[Image: see text] Cathepsin L (CatL) is a lysosomal cysteine protease whose activity has been related to several human pathologies. However, although preclinical trials using CatL inhibitors were promising, clinical trials have been unsuccessful up to now. We are presenting a study of two designed d...

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Detalles Bibliográficos
Autores principales: Fernández-de-la-Pradilla, Adrián, Royo, Santiago, Schirmeister, Tanja, Barthels, Fabian, Świderek, Katarzyna, González, Florenci V., Moliner, Vicent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594577/
https://www.ncbi.nlm.nih.gov/pubmed/37881790
http://dx.doi.org/10.1021/acscatal.3c02748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594577/
https://www.ncbi.nlm.nih.gov/pubmed/37881790
http://dx.doi.org/10.1021/acscatal.3c02748

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