Phosphonate and Thiasugar Analogues of Glucosamine-6-phosphate: Activation of the glmS Riboswitch and Antibiotic Activity

[Image: see text] The glmS riboswitch is a motif found in 5′-untranslated regions of bacterial mRNA that controls the synthesis of glucosamine-6-phosphate (GlcN6P), an essential building block for the bacterial cell wall, by a feedback mechanism. Activation of the glmS riboswitch by GlcN6P mimics in...

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Detalles Bibliográficos
Autores principales: Silkenath, Bjarne, Kläge, Dennis, Altwein, Hanna, Schmidhäuser, Nina, Mayer, Günter, Hartig, Jörg S., Wittmann, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594590/
https://www.ncbi.nlm.nih.gov/pubmed/37793187
http://dx.doi.org/10.1021/acschembio.3c00452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594590/
https://www.ncbi.nlm.nih.gov/pubmed/37793187
http://dx.doi.org/10.1021/acschembio.3c00452

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