Oxidative Cross-Coupling of α-Amino Ketones with Alcohols Enabled by I(2)-Catalyzed C–H Hydroxylation

[Image: see text] An I(2)-catalyzed oxidative cross-coupling of α-amino ketones with a wide range of alcohols is described. Using a combination of air and dimethyl sulfoxide (DMSO) as oxidants, the protocol allows an efficient synthesis of α-carbonyl N,O-acetals with high functional group tolerance...

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Detalles Bibliográficos
Autores principales: Wang, Yingwei, Yang, Mingrong, Lao, Chichou, Wang, Hanxuan, Jiang, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594655/
https://www.ncbi.nlm.nih.gov/pubmed/37807762
http://dx.doi.org/10.1021/acs.joc.3c01469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594655/
https://www.ncbi.nlm.nih.gov/pubmed/37807762
http://dx.doi.org/10.1021/acs.joc.3c01469

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