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An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
BACKGROUND: In vitro incubation of epididymal and vas deferens sperm with Mn(2+) induces Sperm Chromatin Fragmentation (SCF), a mechanism that causes double-stranded breaks in toroid-linker regions (TLRs). Whether this mechanism, thought to require the participation of topoisomerases and/or DNAses a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594720/ https://www.ncbi.nlm.nih.gov/pubmed/37876007 http://dx.doi.org/10.1186/s40659-023-00467-w |