Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction

BACKGROUND: Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is essential for cells to maintain proteostasis and reduce the proteotoxicity caused by these aberrant proteins. When proteasome activity is inadequate, ubiquitinated proteins are sorted into perinuclear aggresomes, whi...

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Detalles Bibliográficos
Autores principales: Zhang, Chenliang, Duan, YiChun, Huang, Chen, Li, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594750/
https://www.ncbi.nlm.nih.gov/pubmed/37872526
http://dx.doi.org/10.1186/s11658-023-00500-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594750/
https://www.ncbi.nlm.nih.gov/pubmed/37872526
http://dx.doi.org/10.1186/s11658-023-00500-6

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