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Genetic Risk Assessment of Degenerative Eye Disease (GRADE): study protocol of a prospective assessment of polygenic risk scores to predict diagnosis of glaucoma and age-related macular degeneration

BACKGROUND: Glaucoma and age-related macular degeneration (AMD) account for a substantial portion of global blindness. Both conditions are highly heritable, with recognised monogenic and polygenic inheritance patterns. Current screening guidelines lack decisive recommendations. Polygenic risk scores...

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Detalles Bibliográficos
Autores principales:	Hollitt, Georgina L, Qassim, Ayub, Thomson, Daniel, Schmidt, Joshua M, Nguyen, Thi Thi, Landers, John, MacGregor, Stuart, Siggs, Owen M, Souzeau, Emmanuelle, Craig, Jamie E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594830/ https://www.ncbi.nlm.nih.gov/pubmed/37875865 http://dx.doi.org/10.1186/s12886-023-03143-5

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