Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages

BACKGROUND: Myelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple sclerosis (MS). Resulting myelin debris hinders repair if not effectively scavenged by Schwann cells and macrophages in PNI and by microglia in SCI and MS....

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Detalles Bibliográficos
Autores principales: Gitik, Miri, Elberg, Gerard, Reichert, Fanny, Tal, Michael, Rotshenker, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594853/
https://www.ncbi.nlm.nih.gov/pubmed/37872624
http://dx.doi.org/10.1186/s12974-023-02929-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594853/
https://www.ncbi.nlm.nih.gov/pubmed/37872624
http://dx.doi.org/10.1186/s12974-023-02929-0

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