Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor

Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is activated by ligand binding, overexpression, or mutation. It is well known for its tyrosine kinase-dependent oncogenic activities in a variety of human cancers. A large number of EGFR inhibitors have been developed for cancer tr...

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Detalles Bibliográficos
Autor principal: Zhang, Yuesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10595022/
https://www.ncbi.nlm.nih.gov/pubmed/37339882
http://dx.doi.org/10.1124/pharmrev.123.000906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10595022/
https://www.ncbi.nlm.nih.gov/pubmed/37339882
http://dx.doi.org/10.1124/pharmrev.123.000906

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