Sinomenine Ameliorates IL-1β-Induced Intervertebral Disc Degeneration in Rats Through Suppressing Inflammation and Oxidative Stress via Keap1/Nrf2/NF-κB Signaling Pathways

PURPOSE: To investigate the molecular mechanism underlying the inhibitory effect of sinomenine (SN) on interleukin-1β (IL-1β)-induced apoptosis in nucleus pulposus cells (NPCs), and to evaluate the potential role of SN in preventing intervertebral disk degeneration (IDD). METHODS: The Rat NPCs were...

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Detalles Bibliográficos
Autores principales: Lu, Gongbiao, Zhang, Cunxin, Li, Kang, Gao, Kai, Fu, Maoqing, Lyu, Chaoliang, Quan, Zhengxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596063/
https://www.ncbi.nlm.nih.gov/pubmed/37881650
http://dx.doi.org/10.2147/JIR.S430423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596063/
https://www.ncbi.nlm.nih.gov/pubmed/37881650
http://dx.doi.org/10.2147/JIR.S430423

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