Cargando…

Sinomenine Ameliorates IL-1β-Induced Intervertebral Disc Degeneration in Rats Through Suppressing Inflammation and Oxidative Stress via Keap1/Nrf2/NF-κB Signaling Pathways

PURPOSE: To investigate the molecular mechanism underlying the inhibitory effect of sinomenine (SN) on interleukin-1β (IL-1β)-induced apoptosis in nucleus pulposus cells (NPCs), and to evaluate the potential role of SN in preventing intervertebral disk degeneration (IDD). METHODS: The Rat NPCs were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Gongbiao, Zhang, Cunxin, Li, Kang, Gao, Kai, Fu, Maoqing, Lyu, Chaoliang, Quan, Zhengxue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596063/ https://www.ncbi.nlm.nih.gov/pubmed/37881650 http://dx.doi.org/10.2147/JIR.S430423

Ejemplares similares

Andrographolide Inhibits Static Mechanical Pressure-Induced Intervertebral Disc Degeneration via the MAPK/Nrf2/HO-1 Pathway
por: Zhang, Cunxin, et al.
Publicado: (2023)

Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway
por: Song, Dawei, et al.
Publicado: (2021)

Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis
por: Sun, Ruping, et al.
Publicado: (2023)

Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration
por: Peng, Pandi, et al.
Publicado: (2022)

Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway
por: Wang, Yanqiu, et al.
Publicado: (2019)

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy
por: Chen, Jiaxing, et al.
Publicado: (2022)

Sinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway
por: Yuan, ManLi, et al.
Publicado: (2021)

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration
por: Tang, Zehan, et al.
Publicado: (2019)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction through Activating the Nrf2/HO-1 Pathway in Intervertebral Disc Degeneration
por: Wang, Ruihong, et al.
Publicado: (2021)

The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights
por: Xiang, Qian, et al.
Publicado: (2022)

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway
por: Liu, Zi-Miao, et al.
Publicado: (2021)

Pathomechanism of intervertebral disc degeneration
por: Oichi, Takeshi, et al.
Publicado: (2020)

Treatment of Intervertebral Disc Degeneration
por: Xin, Jingguo, et al.
Publicado: (2022)

Macrophages and Intervertebral Disc Degeneration
por: Koroth, Jinsha, et al.
Publicado: (2023)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

The involvement of immune system in intervertebral disc herniation and degeneration
por: Ye, Fubiao, et al.
Publicado: (2022)

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
por: Zhang, Guang‐Zhi, et al.
Publicado: (2021)

Exosomes Immunity Strategy: A Novel Approach for Ameliorating Intervertebral Disc Degeneration
por: Li, Weihang, et al.
Publicado: (2022)

Irisin Ameliorates Intervertebral Disc Degeneration by Activating LATS/YAP/CTGF Signaling
por: Chen, Taiqiu, et al.
Publicado: (2022)

Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation
por: Zhang, Fu, et al.
Publicado: (2022)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
por: Munir, Sabrina, et al.
Publicado: (2018)

Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling
por: Chen, Zhiqian, et al.
Publicado: (2021)

Angiogenesis in the degeneration of the lumbar intervertebral disc
por: David, Gh, et al.
Publicado: (2010)

Intervertebral disc degeneration therapies in human
por: Richardson, Stephen M
Publicado: (2015)

Genetic factors in intervertebral disc degeneration
por: Feng, Yi, et al.
Publicado: (2016)

The Role of Adipokines in Intervertebral Disc Degeneration
por: Sharma, Anirudh
Publicado: (2018)

Molecular Mechanisms of Intervertebral Disc Degeneration
por: Rider, Sean M., et al.
Publicado: (2018)

Genetic Therapy for Intervertebral Disc Degeneration
por: Roh, Eun Ji, et al.
Publicado: (2021)

Cervical intervertebral disc degeneration and dizziness
por: Liu, Tang-Hua, et al.
Publicado: (2021)

The Proteolysis of ECM in Intervertebral Disc Degeneration
por: Liang, Huaizhen, et al.
Publicado: (2022)

The role of ferroptosis in intervertebral disc degeneration
por: Fan, Chunyang, et al.
Publicado: (2023)

Role of Necroptosis in Intervertebral Disc Degeneration
por: Khaleque, Md Abdul, et al.
Publicado: (2023)

Nomilin targets the Keap1‐Nrf2 signalling and ameliorates the development of osteoarthritis
por: Xue, Xing‐He, et al.
Publicado: (2020)

The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2005)

Increased caveolin-1 in intervertebral disc degeneration facilitates repair
por: Bach, Frances C., et al.
Publicado: (2016)

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration
por: Liu, Weikun, et al.
Publicado: (2021)

Prolactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-κB pathway in rats
por: Wu, Xiexing, et al.
Publicado: (2018)

Effects of the NF-κB/p53 signaling pathway on intervertebral disc nucleus pulposus degeneration
por: Zhang, Litao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vsdhv04lvafjvmsmt5m3la4jmr