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The nexus of dynamic T cell states and immune checkpoint blockade therapy in the periphery and tumor microenvironment

Immune checkpoint blockade (ICB) therapies, that is, using monoclonal antibodies to reinvigorate tumor-reactive, antigen-specific T cells from the inhibitory effects of CTLA-4, PD-1 and PD-L1 immune checkpoints, have revolutionized the therapeutic landscape of modern oncology. However, only a subset...

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Detalles Bibliográficos
Autores principales: Luo, Hong, Wang, Wenxiang, Mai, Jia, Yin, Rutie, Cai, Xuyu, Li, Qintong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597640/
https://www.ncbi.nlm.nih.gov/pubmed/37881432
http://dx.doi.org/10.3389/fimmu.2023.1267918