Cargando…

DNA damage and repair: underlying mechanisms leading to microcephaly

DNA-damaging agents and endogenous DNA damage constantly harm genome integrity. Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in repairing lesions and preventing mutations in the basic structure of the DNA. Different repair pathways are implicated in the resol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ribeiro, Jessica Honorato, Altinisik, Nazlican, Rajan, Nicholas, Verslegers, Mieke, Baatout, Sarah, Gopalakrishnan, Jay, Quintens, Roel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597653/ https://www.ncbi.nlm.nih.gov/pubmed/37881689 http://dx.doi.org/10.3389/fcell.2023.1268565

Ejemplares similares

An integrative systems biology strategy to support the development of adverse outcome pathways (AOPs): a case study on radiation-induced microcephaly
por: Jaylet, Thomas, et al.
Publicado: (2023)

Human Brain Organoids to Decode Mechanisms of Microcephaly
por: Gabriel, Elke, et al.
Publicado: (2020)

Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure
por: Verreet, Tine, et al.
Publicado: (2016)

Higher Initial DNA Damage and Persistent Cell Cycle Arrest after Carbon Ion Irradiation Compared to X-irradiation in Prostate and Colon Cancer Cells
por: Suetens, Annelies, et al.
Publicado: (2016)

Autosomal Recessive Primary Microcephaly: Not Just a Small Brain
por: Zaqout, Sami, et al.
Publicado: (2022)

Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly
por: Gur, Michal, et al.
Publicado: (2022)

The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus
por: Shohayeb, Belal, et al.
Publicado: (2020)

P53 independent pathogenic mechanisms contribute to BubR1 microcephaly
por: Sterling, Noelle A., et al.
Publicado: (2023)

DNA Damage Response and Repair in Adaptive Immunity
por: Luo, Sha, et al.
Publicado: (2022)

Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer’s disease
por: Coninx, Emma, et al.
Publicado: (2020)

Emerging concepts involving inhibitory and activating RNA functionalization towards the understanding of microcephaly phenotypes and brain diseases in humans
por: Tokunaga, Mayuri, et al.
Publicado: (2023)

Editorial: DNA damage and repair in reproductive and embryo cells
por: Rocco, Lucia, et al.
Publicado: (2023)

Combined Exposure to Simulated Microgravity and Acute or Chronic Radiation Reduces Neuronal Network Integrity and Survival
por: Pani, Giuseppe, et al.
Publicado: (2016)

Biallelic Mutations in ACACA Cause a Disruption in Lipid Homeostasis That Is Associated With Global Developmental Delay, Microcephaly, and Dysmorphic Facial Features
por: Lou, Xiaoting, et al.
Publicado: (2021)

Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair
por: Domingues, Helena S., et al.
Publicado: (2016)

Mutated VWA8 Is Associated With Developmental Delay, Microcephaly, and Scoliosis and Plays a Novel Role in Early Development and Skeletal Morphogenesis in Zebrafish
por: Umair, Muhammad, et al.
Publicado: (2021)

Corrigendum: Oligodendrocyte, Astrocyte and Microglia Crosstalk in Myelin Development, Damage, and Repair
por: Domingues, Helena S., et al.
Publicado: (2016)

Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein
por: An, Hsiao-Lung, et al.
Publicado: (2022)

Tumor Suppressor FBXW7 and Its Regulation of DNA Damage Response and Repair
por: Lan, Huiyin, et al.
Publicado: (2021)

DNA Damage Repair Deficiency in Pancreatic Ductal Adenocarcinoma: Preclinical Models and Clinical Perspectives
por: Stoof, Jojanneke, et al.
Publicado: (2021)

The Capacity to Repair Sperm DNA Damage in Zygotes is Enhanced by Inhibiting WIP1 Activity
por: Leem, Jiyeon, et al.
Publicado: (2022)

Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development
por: Quintens, Roel, et al.
Publicado: (2015)

Increased WIP1 Expression With Aging Suppresses the Capacity of Oocytes to Respond to and Repair DNA Damage
por: Leem, Jiyeon, et al.
Publicado: (2021)

Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer
por: He, Lishu, et al.
Publicado: (2021)

Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs
por: Baiken, Yeldar, et al.
Publicado: (2021)

The mechanism and clinical application of DNA damage repair inhibitors combined with immune checkpoint inhibitors in the treatment of urologic cancer
por: Xie, Deqian, et al.
Publicado: (2023)

Natural Drug-Loaded Bimetal-Substituted Hydroxyapatite-Polymeric Composite for Osteosarcoma-Affected Bone Repair
por: Wang, Yanjun, et al.
Publicado: (2021)

PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair
por: Wang, Yuan, et al.
Publicado: (2021)

Molecular and Clinical Significance of Stanniocalcin-1 Expression in Breast Cancer Through Promotion of Homologous Recombination-Mediated DNA Damage Repair
por: Hou, Jing, et al.
Publicado: (2021)

Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function
por: Pham, Tan Phát, et al.
Publicado: (2021)

Blocking DNA Damage Repair May Be Involved in Stattic (STAT3 Inhibitor)-Induced FLT3-ITD AML Cell Apoptosis
por: Luo, Yuxuan, et al.
Publicado: (2021)

The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways
por: Chen, Zulong, et al.
Publicado: (2022)

Nucleotide Excision Repair and Transcription-coupled DNA Repair Abrogate the Impact of DNA Damage on Transcription
por: Nadkarni, Aditi, et al.
Publicado: (2016)

Maternal Low-Protein Diet Deregulates DNA Repair and DNA Replication Pathways in Female Offspring Mammary Gland Leading to Increased Chemically Induced Rat Carcinogenesis in Adulthood
por: Zapaterini, Joyce R., et al.
Publicado: (2022)

Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair
por: Pears, Catherine J., et al.
Publicado: (2021)

RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination
por: Selemenakis, Platon, et al.
Publicado: (2022)

Dose- and time-dependent gene expression alterations in prostate and colon cancer cells after in vitro exposure to carbon ion and X-irradiation
por: Suetens, Annelies, et al.
Publicado: (2015)

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication
por: Kodani, Andrew, et al.
Publicado: (2015)

The Interaction Efficiency of XPD-p44 With Bulky DNA Damages Depends on the Structure of the Damage
por: Petruseva, Irina, et al.
Publicado: (2021)

The Mitochondrial Response to DNA Damage
por: Rong, Ziye, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pltt282947t4b8nme084l6dkqo