Structural Identification of Impurities in Pioglitazone Hydrochloride Preparations by 2D-UHPLC-Q-Exactive Orbitrap HRMS and Their Toxicity Prediction

Pharmaceutical companies and regulatory agencies have more and more concerns for impurities in pharmaceuticals and their toxicity. In this work, heart-cutting two-dimensional ultrahigh-performance liquid chromatography (2D-UHPLC) in combination with high-resolution mass spectrometry (HRMS) was used,...

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Detalles Bibliográficos
Autores principales: Zhang, Dandan, Wang, Weijian, Zhao, Haiyun, Wang, Song, Yu, Mingyan, Zhang, Dongmei, Liu, Wenkun, Xie, Qiangsheng, Chen, Dejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597724/
https://www.ncbi.nlm.nih.gov/pubmed/37881366
http://dx.doi.org/10.1155/2023/2096521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597724/
https://www.ncbi.nlm.nih.gov/pubmed/37881366
http://dx.doi.org/10.1155/2023/2096521

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