Large-scale manufacturing of base-edited chimeric antigen receptor T cells

Base editing is a revolutionary gene-editing technique enabling the introduction of point mutations into the genome without generating detrimental DNA double-stranded breaks. Base-editing enzymes are commonly delivered in the form of modified linear messenger RNA (mRNA) that is costly to produce. He...

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Detalles Bibliográficos
Autores principales: Woodruff, Rosie, Parekh, Farhaan, Lamb, Katarina, Mekkaoui, Leila, Allen, Christopher, Smetanova, Katerina, Huang, Jasmine, Williams, Alex, Toledo, Gerardo Santiago, Lilova, Koki, Roddie, Claire, Sillibourne, James, Pule, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597784/
https://www.ncbi.nlm.nih.gov/pubmed/37886606
http://dx.doi.org/10.1016/j.omtm.2023.101123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597784/
https://www.ncbi.nlm.nih.gov/pubmed/37886606
http://dx.doi.org/10.1016/j.omtm.2023.101123

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