PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma

The PDCD1-encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). The highest frequencies of PDCD1 deletions are detected in advanced disease, predicting inferior prognosis. However, the tumor-suppressive...

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Detalles Bibliográficos
Autores principales: Wartewig, Tim, Daniels, Jay, Schulz, Miriam, Hameister, Erik, Joshi, Abhinav, Park, Joonhee, Morrish, Emma, Venkatasubramani, Anuroop V., Cernilogar, Filippo M., van Heijster, Frits H. A., Hundshammer, Christian, Schneider, Heike, Konstantinidis, Filippos, Gabler, Judith V., Klement, Christine, Kurniawan, Henry, Law, Calvin, Lee, Yujin, Choi, Sara, Guitart, Joan, Forne, Ignasi, Giustinani, Jérôme, Müschen, Markus, Jain, Salvia, Weinstock, David M., Rad, Roland, Ortonne, Nicolas, Schilling, Franz, Schotta, Gunnar, Imhof, Axel, Brenner, Dirk, Choi, Jaehyuk, Ruland, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597841/
https://www.ncbi.nlm.nih.gov/pubmed/37723306
http://dx.doi.org/10.1038/s43018-023-00635-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597841/
https://www.ncbi.nlm.nih.gov/pubmed/37723306
http://dx.doi.org/10.1038/s43018-023-00635-7

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