De novo design of knotted tandem repeat proteins

De novo protein design methods can create proteins with folds not yet seen in nature. These methods largely focus on optimizing the compatibility between the designed sequence and the intended conformation, without explicit consideration of protein folding pathways. Deeply knotted proteins, whose to...

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Detalles Bibliográficos
Autores principales: Doyle, Lindsey A., Takushi, Brittany, Kibler, Ryan D., Milles, Lukas F., Orozco, Carolina T., Jones, Jonathan D., Jackson, Sophie E., Stoddard, Barry L., Bradley, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598012/
https://www.ncbi.nlm.nih.gov/pubmed/37875492
http://dx.doi.org/10.1038/s41467-023-42388-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598012/
https://www.ncbi.nlm.nih.gov/pubmed/37875492
http://dx.doi.org/10.1038/s41467-023-42388-y

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