Cargando…

Identification of ONECUT3 as a stemness-related transcription factor regulating NK cell-mediated immune evasion in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) has a dismal response to the current T cell-based immunotherapies, which is attributed to intratumoral heterogeneity caused by PDAC stem cells and lack of major histocompatibility complex class I required for neoantigen presentation. Although this scenario mak...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Haojun, Tsang, Yiusing, Yang, Yisi, Chin, Hok Leong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598193/ https://www.ncbi.nlm.nih.gov/pubmed/37875589 http://dx.doi.org/10.1038/s41598-023-45560-y

Ejemplares similares

Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer
por: Shi, Haojun, et al.
Publicado: (2022)

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
por: Heller, Sandra, et al.
Publicado: (2021)

Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells
por: Shi, Haojun, et al.
Publicado: (2021)

Transcriptomic analyses of Onecut1 and Onecut2 deficient retinas
por: Goetz, Jillian J., et al.
Publicado: (2015)

Onecut transcription factors in retinal development and maintenance
por: Sapkota, Darshan, et al.
Publicado: (2015)

Onecut1 and Onecut2 Play Critical Roles in the Development of the Mouse Retina
por: Goetz, Jillian J., et al.
Publicado: (2014)

Correction: Onecut1 and Onecut2 Play Critical Roles in the Development of the Mouse Retina
Publicado: (2014)

ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility
por: van der Raadt, Jori, et al.
Publicado: (2019)

Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6
por: Kropp, Peter A., et al.
Publicado: (2019)

Dose-dependent regulation of horizontal cell fate by Onecut family of transcription factors
por: Kreplova, Michaela, et al.
Publicado: (2020)

Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1
por: Jean-Charles, Nathalie, et al.
Publicado: (2018)

Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling
por: Peng, Jei-Ming, et al.
Publicado: (2022)

The Onecut Transcription Factor HNF-6 Regulates in Motor Neurons the Formation of the Neuromuscular Junctions
por: Audouard, Emilie, et al.
Publicado: (2012)

ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY
por: Liu, Danfei, et al.
Publicado: (2021)

Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases
por: Sim, Wynne, et al.
Publicado: (2022)

ONECUT2 is a driver of neuroendocrine prostate cancer
por: Guo, Haiyang, et al.
Publicado: (2019)

Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion
por: Zhang, Shunchuan, et al.
Publicado: (2021)

The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development
por: Kabayiza, Karolina U., et al.
Publicado: (2017)

Correction to: ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY
por: Liu, Danfei, et al.
Publicado: (2021)

Autonomous action and cooperativity between the ONECUT2 transcription factor and its 3′ untranslated region
por: Steadman, Kenneth, et al.
Publicado: (2023)

A “vicious cycle” of NK-cell immune evasion in acute myeloid leukemia mediated by RANKL?
por: Schmiedel, Benjamin Joachim, et al.
Publicado: (2013)

P056: Variants of the transcription factor ONECUT2 regulate gene expression in Hodgkin Lymphoma cells
por: Lein, Patricia, et al.
Publicado: (2022)

Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
por: Kaochar, Salma, et al.
Publicado: (2019)

Molecular Mechanisms and Potential Therapeutic Reversal of Pancreatic Cancer-Induced Immune Evasion
por: Gan, Li-Lian, et al.
Publicado: (2020)

Immune evasion by cancer stem cells
por: Tsuchiya, Hiroyuki, et al.
Publicado: (2021)

ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression
por: Ma, Qingyang, et al.
Publicado: (2019)

Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation
por: Vassalli, Quirino Attilio, et al.
Publicado: (2021)

Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits
por: Toch, Mathilde, et al.
Publicado: (2020)

Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy
por: Martinez-Bosch, Neus, et al.
Publicado: (2018)

Underlying mechanisms of evasion from NK cells as rationale for improvement of NK cell-based immunotherapies
por: Seliger, Barbara, et al.
Publicado: (2022)

T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion
por: Morton, Laura T, et al.
Publicado: (2022)

Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells
por: Patoori, Sruti, et al.
Publicado: (2020)

ONECUT2 as a new therapeutic target in androgen receptor-indifferent prostate cancer
por: Freeman, Michael R., et al.
Publicado: (2019)

Author Correction: Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits
por: Toch, Mathilde, et al.
Publicado: (2020)

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
por: Cheung, Phyllis F., et al.
Publicado: (2022)

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
por: Yamamoto, Keisuke, et al.
Publicado: (2020)

KRAS drives immune evasion in a genetic model of pancreatic cancer
por: Ischenko, Irene, et al.
Publicado: (2021)

Tryptophan metabolism promotes immune evasion in human pancreatic β cells
por: Rachdi, Latif, et al.
Publicado: (2023)

ONECUT2 Accelerates Tumor Proliferation Through Activating ROCK1 Expression in Gastric Cancer
por: Chen, Jie, et al.
Publicado: (2020)

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer
por: Qian, Chen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cgievsa1sg1rfirhm1vl2v4dsv