Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more common than amplification in sarcomas and it might be a rati...

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Detalles Bibliográficos
Autores principales: Martin-Broto, Javier, Martinez-Garcia, Jeronimo, Moura, David S., Redondo, Andres, Gutierrez, Antonio, Lopez-Pousa, Antonio, Martinez-Trufero, Javier, Sevilla, Isabel, Diaz-Beveridge, Roberto, Solis-Hernandez, Maria Pilar, Carnero, Amancio, Perez, Marco, Marcilla, David, Garcia-Foncillas, Jesus, Romero, Pablo, Fernandez-Jara, Javier, Lopez-Lopez, Daniel, Arribas, Ivan, Hindi, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598203/
https://www.ncbi.nlm.nih.gov/pubmed/37875500
http://dx.doi.org/10.1038/s41392-023-01661-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598203/
https://www.ncbi.nlm.nih.gov/pubmed/37875500
http://dx.doi.org/10.1038/s41392-023-01661-8

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