Structural insights for selective disruption of Beclin 1 binding to Bcl-2

Stimulation of autophagy could provide powerful therapies for multiple diseases, including cancer and neurodegeneration. An attractive drug target for this purpose is Bcl-2, which inhibits autophagy by binding to the Beclin 1 BH3-domain. However, compounds that preclude Beclin 1/Bcl-2 binding might...

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Detalles Bibliográficos
Autores principales: Pan, Yun-Zu, Liang, Qiren, Tomchick, Diana R., De Brabander, Jef K., Rizo, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598227/
https://www.ncbi.nlm.nih.gov/pubmed/37875561
http://dx.doi.org/10.1038/s42003-023-05467-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598227/
https://www.ncbi.nlm.nih.gov/pubmed/37875561
http://dx.doi.org/10.1038/s42003-023-05467-w

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