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Crystallographic cyanide-probing for cytochrome c oxidase reveals structural bases suggesting that a putative proton transfer H-pathway pumps protons

Cytochrome c oxidase (CcO) reduces O(2) in the O(2)-reduction site by sequential four-electron donations through the low-potential metal sites (Cu(A) and Fe(a)). Redox-coupled X-ray crystal structural changes have been identified at five distinct sites including Asp(51), Arg(438), Glu(198), the hydr...

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Detalles Bibliográficos
Autores principales: Shimada, Atsuhiro, Baba, Jumpei, Nagao, Shuhei, Shinzawa-Itoh, Kyoko, Yamashita, Eiki, Muramoto, Kazumasa, Tsukihara, Tomitake, Yoshikawa, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598403/
https://www.ncbi.nlm.nih.gov/pubmed/37742916
http://dx.doi.org/10.1016/j.jbc.2023.105277