Role of mu opioid receptor (MOR) agonist efficacy as a determinant of opioid antinociception in a novel assay of pain-depressed behavior in female and male mice

INTRODUCTION: Intermediate efficacy mu opioid receptor (MOR) agonists have potential to retain analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective and safe opioid analgesia is unknown. Preclinical assays of pain-depressed behavior can assess effects of opioids...

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Detalles Bibliográficos
Autores principales: Negus, S. Stevens, Akbarali, Hamid I., Kang, Minho, Lee, Young K., Marsh, Samuel A., Santos, Edna J., Zhang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pain Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598607/
https://www.ncbi.nlm.nih.gov/pubmed/37886350
http://dx.doi.org/10.3389/fpain.2023.1281698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598607/
https://www.ncbi.nlm.nih.gov/pubmed/37886350
http://dx.doi.org/10.3389/fpain.2023.1281698

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