Cargando…

Role of mu opioid receptor (MOR) agonist efficacy as a determinant of opioid antinociception in a novel assay of pain-depressed behavior in female and male mice

INTRODUCTION: Intermediate efficacy mu opioid receptor (MOR) agonists have potential to retain analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective and safe opioid analgesia is unknown. Preclinical assays of pain-depressed behavior can assess effects of opioids...

Descripción completa

Detalles Bibliográficos
Autores principales:	Negus, S. Stevens, Akbarali, Hamid I., Kang, Minho, Lee, Young K., Marsh, Samuel A., Santos, Edna J., Zhang, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pain Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598607/ https://www.ncbi.nlm.nih.gov/pubmed/37886350 http://dx.doi.org/10.3389/fpain.2023.1281698

Ejemplares similares

Role of efficacy as a determinant of locomotor activation by mu‐opioid receptor (MOR) ligands in female and male mice. II. Effects of novel MOR‐selective phenylmorphans with high‐to‐low MOR efficacy
por: Santos, Edna J., et al.
Publicado: (2023)

Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene
por: Chen, Shiou-Lan, et al.
Publicado: (2010)

Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia
por: Oladosu, Folabomi A., et al.
Publicado: (2015)

Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys
por: Negus, S. Stevens, et al.
Publicado: (2012)

In vivo and in vitro Characterization of a Partial Mu Opioid Receptor Agonist, NKTR-181, Supports Future Therapeutic Development
por: Lee, Alex S., et al.
Publicado: (2021)

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera
por: Guillemyn, Karel, et al.
Publicado: (2012)

Association of Mu-Opioid Receptor(MOR) Expression and Opioids Requirement With Survival in Patients With Stage I-III Pancreatic Ductal Adenocarcinoma
por: Zhang, Hao, et al.
Publicado: (2021)

Chronic Pelvic Pain and Sexual Dysfunction Among Females and Males Receiving Treatment for Opioid Use Disorder
por: Reichmann, Geetika, et al.
Publicado: (2022)

Impact of opioid rescue medication for breakthrough pain on the efficacy and tolerability of long-acting opioids in patients with chronic non-malignant pain
por: Devulder, J., et al.
Publicado: (2009)

Morphine Exacerbates Experimental Colitis-Induced Depression of Nesting in Mice
por: Cheatham, Stanley M., et al.
Publicado: (2021)

The opioid epidemic: helping rheumatologists prevent a crisis
por: Trouvin, Anne-Priscille, et al.
Publicado: (2019)

Associations between postpartum pain type, pain intensity and opioid use in patients with and without opioid use disorder: a cross-sectional study
por: Lim, Grace, et al.
Publicado: (2023)

Chronic Ethanol Consumption in Rats Produces Opioid Antinociceptive Tolerance through Inhibition of Mu Opioid Receptor Endocytosis
por: He, Li, et al.
Publicado: (2011)

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists
por: Murányi, Marianna, et al.
Publicado: (2013)

Vimentin interacts with the 5′-untranslated region of mouse mu opioid receptor (MOR) and is required for post-transcriptional regulation
por: Song, Kyu Young, et al.
Publicado: (2013)

The Hypnotic, Anxiolytic, and Antinociceptive Profile of a Novel µ-Opioid Agonist
por: Montes, Guilherme Carneiro, et al.
Publicado: (2017)

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966
por: Reichenbach, Zachary W., et al.
Publicado: (2022)

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys
por: Aceto, Mario D., et al.
Publicado: (2012)

Pain Management in Oncology Patients Amidst the Opioid Epidemic: How To Minimize Non-Medical Opioid Use
por: Chahin, Michael, et al.
Publicado: (2021)

Overdose, opioid treatment admissions and prescription opioid pain reliever relationships: United States, 2010–2019
por: Aubry, Larry, et al.
Publicado: (2022)

Suicide by Opioid: Exploring the Intentionality of the Act
por: Pergolizzi, Joseph, et al.
Publicado: (2021)

Biased Opioid Ligands: Revolution or Evolution?
por: Noble, Florence, et al.
Publicado: (2021)

A Retrospective Analysis of the Safety and Efficacy of Opioid-free Anesthesia versus Opioid Anesthesia for General Cesarean Section
por: Enten, Garrett, et al.
Publicado: (2019)

Corrigendum: Overdose, opioid treatment admissions and prescription opioid pain reliever relationships: United States, 2010–2019
Publicado: (2023)

Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors
por: Shen, Qianwei, et al.
Publicado: (2017)

Case report: The lesson from opioid withdrawal symptoms mimicking paraganglioma recurrence during opioid deprescribing in cancer pain
por: Ruggiero, Elena, et al.
Publicado: (2023)

Molecular Physiology of Enteric Opioid Receptors
por: Galligan, James J., et al.
Publicado: (2014)

Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D(2) Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
por: Vasudevan, Lakshmi, et al.
Publicado: (2019)

GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice
por: Ram, Akila, et al.
Publicado: (2021)

A Review of the Opioid Analgesic Benzhydrocodone-Acetaminophen
por: Mustafa, Ahmaya A, et al.
Publicado: (2018)

Multiple Opioid Prescribers During the Perioperative Period Increases Opioid Consumption Following Upper Extremity Surgery: A Multicenter Analysis
por: Paladino, Joseph, et al.
Publicado: (2022)

The Impact of Non-opioid Analgesic Usage on Total Opioid Load During Traumatic Brain Injury Rehabilitation: A Retrospective Study
por: King, Joshua D, et al.
Publicado: (2023)

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity
por: Greedy, Benjamin M., et al.
Publicado: (2013)

Climbing behavior by mice as an endpoint for preclinical assessment of drug effects in the absence and presence of pain
por: Santos, Edna J., et al.
Publicado: (2023)

Efficacy and Safety of Peripherally Acting μ-Opioid Receptor Antagonist (PAMORAs) for the Management of Patients With Opioid-Induced Constipation: A Systematic Review
por: Rekatsina, Martina, et al.
Publicado: (2021)

Transition From Full Mu Opioid Agonists to Buprenorphine in Opioid Dependent Patients—A Critical Review
por: Soyka, Michael
Publicado: (2021)

A Review of Samidorphan: A Novel Opioid Antagonist
por: Chaudhary, Amna Mohyud Din, et al.
Publicado: (2019)

Opioids and Chronic Pain: An Analytic Review of the Clinical Evidence
por: Nadeau, Stephen E., et al.
Publicado: (2021)

The opioid receptor: emergence through millennia of pharmaceutical sciences
por: Fairbanks, Carolyn A., et al.
Publicado: (2023)

Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
por: Kim, Chun Sung, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_psphuociu1pq4f5bk86e50f8r4