Structural insights into Rad18 targeting by the SLF1 BRCT domains

Rad18 interacts with the SMC5/6 localization factor 1 (SLF1) to recruit the SMC5/6 complex to DNA damage sites for repair. The mechanism of the specific Rad18 recognition by SLF1 is unclear. Here, we present the crystal structure of the tandem BRCT repeat (tBRCT) in SLF1 (SLF1(tBRCT)) bound with the...

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Detalles Bibliográficos
Autores principales: Huang, Wei, Qiu, Fangjie, Zheng, Lin, Shi, Meng, Shen, Miaomiao, Zhao, Xiaolan, Xiang, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598736/
https://www.ncbi.nlm.nih.gov/pubmed/37748650
http://dx.doi.org/10.1016/j.jbc.2023.105288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598736/
https://www.ncbi.nlm.nih.gov/pubmed/37748650
http://dx.doi.org/10.1016/j.jbc.2023.105288

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