VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells

We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the present study was to elucidate the mechanisms by which VRK3 depletion impact DMG-H3K27M cell fitness. Gene expression studies after VRK3 knockdown...

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Detalles Bibliográficos
Autores principales: Menez, Virginie, Kergrohen, Thomas, Shasha, Tal, Silva-Evangelista, Claudia, Le Dret, Ludivine, Auffret, Lucie, Subecz, Chloé, Lancien, Manon, Ajlil, Yassine, Vilchis, Irma Segoviano, Beccaria, Kévin, Blauwblomme, Thomas, Oberlin, Estelle, Grill, Jacques, Castel, David, Debily, Marie-Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599138/
https://www.ncbi.nlm.nih.gov/pubmed/37886173
http://dx.doi.org/10.3389/fonc.2023.1229312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599138/
https://www.ncbi.nlm.nih.gov/pubmed/37886173
http://dx.doi.org/10.3389/fonc.2023.1229312

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