CD39(+) conventional CD4(+) T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

Conventional CD4(+) T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to tumor elimination remains poorly understood. Here, we describe a subset of tumor-infiltrating Tconv cells characterized by the expression of CD39. In several mouse cancer models, we obser...

Descripción completa

Detalles Bibliográficos
Autores principales: Bossio, Sabrina N., Abrate, Carolina, Tosello Boari, Jimena, Rodriguez, Constanza, Canale, Fernando P., Ramello, María C., Brunotto, Valentina, Richer, Wilfrid, Rocha, Dario, Sedlik, Christine, Vincent-Salomon, Anne, Borcoman, Edith, Del Castillo, Andres, Gruppi, Adriana, Fernandez, Elmer, Acosta Rodríguez, Eva V., Piaggio, Eliane, Montes, Carolina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599196/
https://www.ncbi.nlm.nih.gov/pubmed/37885970
http://dx.doi.org/10.1080/2162402X.2023.2246319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599196/
https://www.ncbi.nlm.nih.gov/pubmed/37885970
http://dx.doi.org/10.1080/2162402X.2023.2246319

Ejemplares similares