High In Vitro and In Vivo Activity of BI-847325, a Dual MEK/Aurora Kinase Inhibitor, in Human Solid and Hematologic Cancer Models

BI-847325 is an ATP-competitive inhibitor of MEK/Aurora kinases with the potential to treat a wide range of cancers. In a panel of 294 human tumor cell lines in vitro, BI-847325 was found to be a highly selective inhibitor that was active in the submicromolar range. The most sensitive cancer types w...

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Detalles Bibliográficos
Autores principales: Vuaroqueaux, Vincent, Musch, Alexandra, Peille, Anne-Lise, Kelter, Gerhard, Weichert, Loreen, Metz, Thomas, Hendriks, Hans R., Fiebig, Heinz-Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599287/
https://www.ncbi.nlm.nih.gov/pubmed/37830744
http://dx.doi.org/10.1158/2767-9764.CRC-22-0221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599287/
https://www.ncbi.nlm.nih.gov/pubmed/37830744
http://dx.doi.org/10.1158/2767-9764.CRC-22-0221

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