High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life

Heteroplasmic mitochondrial DNA (mtDNA) mutations are a major cause of inherited disease and contribute to common late-onset human disorders. The late onset and clinical progression of mtDNA-associated disease is thought to be due to changing heteroplasmy levels, but it is not known how and when thi...

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Detalles Bibliográficos
Autores principales: Glynos, Angelos, Bozhilova, Lyuba V., Frison, Michele, Burr, Stephen, Stewart, James B., Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599618/
https://www.ncbi.nlm.nih.gov/pubmed/37878704
http://dx.doi.org/10.1126/sciadv.adi4038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599618/
https://www.ncbi.nlm.nih.gov/pubmed/37878704
http://dx.doi.org/10.1126/sciadv.adi4038

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