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High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life
Heteroplasmic mitochondrial DNA (mtDNA) mutations are a major cause of inherited disease and contribute to common late-onset human disorders. The late onset and clinical progression of mtDNA-associated disease is thought to be due to changing heteroplasmy levels, but it is not known how and when thi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599618/ https://www.ncbi.nlm.nih.gov/pubmed/37878704 http://dx.doi.org/10.1126/sciadv.adi4038 |