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Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study

BACKGROUND: Findings from Mendelian randomization (MR) studies are conventionally interpreted as lifelong effects, which typically do not provide insight into the molecular mechanisms underlying the effect of an exposure on an outcome. In this study, we apply two recently developed MR approaches (kn...

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Detalles Bibliográficos
Autores principales: Richardson, Tom G, Leyden, Genevieve M, Davey Smith, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599655/
https://www.ncbi.nlm.nih.gov/pubmed/37878001
http://dx.doi.org/10.7554/eLife.84646