Cargando…

Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study

BACKGROUND: Findings from Mendelian randomization (MR) studies are conventionally interpreted as lifelong effects, which typically do not provide insight into the molecular mechanisms underlying the effect of an exposure on an outcome. In this study, we apply two recently developed MR approaches (kn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richardson, Tom G, Leyden, Genevieve M, Davey Smith, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Epidemiology and Global Health
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599655/ https://www.ncbi.nlm.nih.gov/pubmed/37878001 http://dx.doi.org/10.7554/eLife.84646

Ejemplares similares

Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study
por: Richardson, Tom G, et al.
Publicado: (2022)

A lifecourse Mendelian randomization study uncovers age-dependent effects of adiposity on asthma risk
por: Urquijo, Helena, et al.
Publicado: (2023)

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health
por: Davies, Neil Martin, et al.
Publicado: (2019)

Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization
por: Richardson, Tom G, et al.
Publicado: (2023)

Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study
por: Howe, Laurence J, et al.
Publicado: (2022)

Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity
por: Carrasquilla, Germán D, et al.
Publicado: (2022)

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
por: Martin, Susan, et al.
Publicado: (2022)

Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers
por: Fang, Si, et al.
Publicado: (2022)

Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
por: Martin, Susan, et al.
Publicado: (2022)

Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study
por: Hughes, Amanda M, et al.
Publicado: (2022)

Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis
por: Yuan, Shuai, et al.
Publicado: (2023)

Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study
por: Huang, Wuqing, et al.
Publicado: (2021)

Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study
por: Zhao, Sizheng Steven, et al.
Publicado: (2022)

Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor
por: Liu, Hui, et al.
Publicado: (2021)

Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation
por: Schooling, CM, et al.
Publicado: (2020)

Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome
por: Cortez Cardoso Penha, Ricardo, et al.
Publicado: (2023)

The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria
por: Zhu, Sha Joe, et al.
Publicado: (2019)

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization
por: Sanderson, Eleanor, et al.
Publicado: (2022)

Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases
por: Sobczyk, Maria K, et al.
Publicado: (2023)

Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries
por: Li, Xinxuan, et al.
Publicado: (2022)

A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure
por: O’Nunain, Katie, et al.
Publicado: (2022)

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation
por: Richardson, Tom G., et al.
Publicado: (2022)

Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation
por: Leyden, Genevieve M., et al.
Publicado: (2022)

A modular approach to integrating multiple data sources into real-time clinical prediction for pediatric diarrhea
por: Brintz, Ben J, et al.
Publicado: (2021)

Impact of vaping introduction on cigarette smoking in six jurisdictions with varied regulatory approaches to vaping: an interrupted time series analysis
por: Wu, Daphne C, et al.
Publicado: (2022)

Quantifying antibody kinetics and RNA detection during early-phase SARS-CoV-2 infection by time since symptom onset
por: Borremans, Benny, et al.
Publicado: (2020)

A Global lmmunological Observatory to meet a time of pandemics
por: Mina, Michael J, et al.
Publicado: (2020)

Time-to-event modeling of hypertension reveals the nonexistence of true controls
por: Shriner, Daniel, et al.
Publicado: (2020)

Inference of the SARS-CoV-2 generation time using UK household data
por: Hart, William S, et al.
Publicado: (2022)

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
por: Richardson, Tom G., et al.
Publicado: (2020)

Association between genetically determined leptin and blood lipids considering alcohol consumption: a Mendelian randomisation study
por: Shen, Luqi, et al.
Publicado: (2019)

3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography
por: Reichardt, Marius, et al.
Publicado: (2021)

The impact of lag time to cancer diagnosis and treatment on clinical outcomes prior to the COVID-19 pandemic: A scoping review of systematic reviews and meta-analyses
por: Tope, Parker, et al.
Publicado: (2023)

Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020
por: Coppée, Romain, et al.
Publicado: (2023)

Eleven key measures for monitoring general practice clinical activity during COVID-19: A retrospective cohort study using 48 million adults’ primary care records in England through OpenSAFELY
por: Fisher, Louis, et al.
Publicado: (2023)

Interpretation of Mendelian randomization using a single measure of an exposure that varies over time
por: Morris, Tim T, et al.
Publicado: (2022)

Mathematical modeling of the West Africa Ebola epidemic
por: Chretien, Jean-Paul, et al.
Publicado: (2015)

Ontogeny of circulating lipid metabolism in pregnancy and early childhood – a longitudinal population study
por: Burugupalli, Satvika, et al.
Publicado: (2022)

Impact of COVID-19 pandemic on breast and cervical cancer screening in Denmark: A register-based study
por: Nonboe, Mette Hartmann, et al.
Publicado: (2023)

A modelled analysis of the impact of COVID-19-related disruptions to HPV vaccination
por: Velentzis, Louiza S, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cffucgfrfs3qfveaivgkdh9srj