Robustness of quantifying mediating effects of genetically regulated expression on complex traits with mediated expression score regression

Genetic association signals have been mostly found in noncoding regions through genome-wide association studies (GWAS), suggesting the roles of gene expression regulation in human diseases and traits. However, there has been limited success in colocalizing expression quantitative trait locus (eQTL)...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Chen, Liu, Wei, Jiang, Wei, Zhao, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599978/
https://www.ncbi.nlm.nih.gov/pubmed/37901453
http://dx.doi.org/10.1093/biomethods/bpad024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599978/
https://www.ncbi.nlm.nih.gov/pubmed/37901453
http://dx.doi.org/10.1093/biomethods/bpad024

Ejemplares similares