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Robustness of quantifying mediating effects of genetically regulated expression on complex traits with mediated expression score regression
Genetic association signals have been mostly found in noncoding regions through genome-wide association studies (GWAS), suggesting the roles of gene expression regulation in human diseases and traits. However, there has been limited success in colocalizing expression quantitative trait locus (eQTL)...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599978/ https://www.ncbi.nlm.nih.gov/pubmed/37901453 http://dx.doi.org/10.1093/biomethods/bpad024 |