Cargando…

Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb

Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist(1), has revolutionized the treatment of depression because of its potent, rapid and sustained antidepressant effects(2–4). Although the elimination half-life of ketamine is only 13 min in mice(5), its antidepressant activities can last fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Shuangshuang, Chen, Min, Jiang, Yihao, Xiang, Xinkuan, Wang, Shiqi, Wu, Zuohang, Li, Shuo, Cui, Yihui, Wang, Junying, Zhu, Yanqing, Zhang, Yan, Ma, Huan, Duan, Shumin, Li, Haohong, Yang, Yan, Lingle, Christopher J., Hu, Hailan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600008/ https://www.ncbi.nlm.nih.gov/pubmed/37853123 http://dx.doi.org/10.1038/s41586-023-06624-1

Ejemplares similares

Author Correction: Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb
por: Ma, Shuangshuang, et al.
Publicado: (2023)

NMDAR inhibition-independent antidepressant actions of ketamine metabolites
por: Zanos, Panos, et al.
Publicado: (2016)

The LHB experiment
por: Waldi, R
Publicado: (1994)

A muon trigger for LHB
por: Santacesaria, R
Publicado: (1994)

Lhb(−/−)Lhr(−/−) Double Mutant Mice Phenocopy Lhb(−/−) or Lhr(−/−) Single Mutants and Display Defects in Leydig Cells and Steroidogenesis
por: Liu, Zhenghui, et al.
Publicado: (2022)

Male hypogonadism caused by a homozygous missense mutation of the LHB gene
por: Chen, Jie, et al.
Publicado: (2021)

The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders
por: Shor, Chaya, et al.
Publicado: (2020)

Ketamine Induces Lasting Antidepressant Effects by Modulating the NMDAR/CaMKII-Mediated Synaptic Plasticity of the Hippocampal Dentate Gyrus in Depressive Stroke Model
por: Abdoulaye, Idriss Ali, et al.
Publicado: (2021)

NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms
por: Lee, Boyoung, et al.
Publicado: (2020)

Ketamine: stimulating antidepressant treatment?
por: Malhi, Gin S., et al.
Publicado: (2016)

Immunoregulation and antidepressant effect of ketamine
por: Zhang, Nan, et al.
Publicado: (2021)

Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients
por: Abdallah, Chadi G., et al.
Publicado: (2018)

Genomics and genetics of gonadotropin beta-subunit genes: Unique FSHB and duplicated LHB/CGB loci
por: Nagirnaja, Liina, et al.
Publicado: (2010)

The Ketamine Antidepressant Story: New Insights
por: Alshammari, Tahani K.
Publicado: (2020)

The role of dissociation in ketamine’s antidepressant effects
por: Ballard, Elizabeth D., et al.
Publicado: (2020)

The antidepressant properties of ketamine (literature review)
por: Chamsi, F. Z., et al.
Publicado: (2023)

SAT-420 Gonadotropin-Releasing Hormone Stimulates Luteinizing Hormone Exocytosis without Elevating Lhb Expression
por: Janjic, Marija, et al.
Publicado: (2019)

Validation of the NEOS score in Chinese patients with anti-NMDAR encephalitis
por: Peng, Yujing, et al.
Publicado: (2020)

Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
por: Browne, Caroline A., et al.
Publicado: (2013)

OR2801 Novel Cis-Regulatory Mechanisms Of Lhb Transcription By Non-Coding RNAs And Non-Canonical DNA Structures
por: Refael, Tal, et al.
Publicado: (2023)

Ketamine as Antidepressant? Current State and Future Perspectives
por: Hasselmann, H. W.W.
Publicado: (2014)

Is Metabolism of (R)-Ketamine Essential for the Antidepressant Effects?
por: Chaki, Shigeyuki
Publicado: (2017)

Structural Integrity in the Sustained Antidepressant Effect of Ketamine
por: Belujon, Pauline
Publicado: (2017)

Ketamine: a new chapter in antidepressant development
por: Zarate, Carlos A.
Publicado: (2020)

Association of plasma VEGF levels and the antidepressant effects of ketamine in patients with depression
por: Zheng, Wei, et al.
Publicado: (2021)

Activation of σ1-Receptors by R-Ketamine May Enhance the Antidepressant Effect of S-Ketamine
por: Kalkman, Hans O.
Publicado: (2023)

Effect of Ketamine on LTP and NMDAR EPSC in Hippocampus of the Chronic Social Defeat Stress Mice Model of Depression
por: Yang, Yu, et al.
Publicado: (2018)

Rapid Antidepressant Response with Ketamine: Is it the Solution to Resistant Depression?
por: Thakurta, Rajarshi Guha, et al.
Publicado: (2012)

Acute Antidepressant Effects of Intramuscular Versus Intravenous Ketamine
por: Chilukuri, Harihar, et al.
Publicado: (2014)

Antidepressant mechanism of ketamine: perspective from preclinical studies
por: Scheuing, Lisa, et al.
Publicado: (2015)

Beyond Ketamine: New Approaches to the Development of Safer Antidepressants
por: Chaki, Shigeyuki
Publicado: (2017)

The Antidepressant Effect of Ketamine Is Dampened by Concomitant Benzodiazepine Medication
por: Andrashko, Veronika, et al.
Publicado: (2020)

Uncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant
por: Xu, Songbai, et al.
Publicado: (2022)

Plasma BDNF concentrations and the antidepressant effects of six ketamine infusions in unipolar and bipolar depression
por: Zheng, Wei, et al.
Publicado: (2021)

A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action
por: Lin, Pei-Yi, et al.
Publicado: (2021)

BDNF and the Antidepressant Effects of Ketamine and Propofol in Electroconvulsive Therapy: A Preliminary Study
por: Huang, Xing-Bing, et al.
Publicado: (2020)

Cytokine/chemokine levels in the CSF and serum of anti-NMDAR encephalitis: A systematic review and meta-analysis
por: Ma, Yushan, et al.
Publicado: (2023)

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
por: Yang, C, et al.
Publicado: (2015)

Studying pre-treatment and ketamine-induced changes in white matter microstructure in the context of ketamine’s antidepressant effects
por: Sydnor, Valerie J., et al.
Publicado: (2020)

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression
por: Yang, Bangkun, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fumgc3cbenu71ikrfbkkla2e1a