Diminazene aceturate or losartan ameliorates the functional, radiological and histopathological alterations in knee osteoarthritis rodent model: repurposing of the ACE2/Ang1-7/MasR cascade

PURPOSE: Current therapies for osteoarthritis (OA) are limited to analgesics and anti-inflammatory drugs. Considering the importance of oxidative stress and inflammatory mediators in OA etiology, we tested the hypothesis that targeting the renin–angiotensin–aldosterone system (RAAS) can improve OA a...

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Detalles Bibliográficos
Autores principales: Habib, Yasser H., Sheta, Eman, Khattab, Mahmoud, Gowayed, Mennatallah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600085/
https://www.ncbi.nlm.nih.gov/pubmed/37878123
http://dx.doi.org/10.1186/s40634-023-00673-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600085/
https://www.ncbi.nlm.nih.gov/pubmed/37878123
http://dx.doi.org/10.1186/s40634-023-00673-1

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