Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8(+) T cells

Antigen cognate dendritic cell (DC)-T cell synaptic interactions drive activation of T cells and instruct DCs. Upon receiving CD4(+) T cell help, post-synaptic DCs (psDCs) are licensed to generate CD8(+) T cell responses. However, the cellular and molecular mechanisms that enable psDCs licensing rem...

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Detalles Bibliográficos
Autores principales: Calzada-Fraile, Diego, Iborra, Salvador, Ramírez-Huesca, Marta, Jorge, Inmaculada, Dotta, Enrico, Hernández-García, Elena, Martín-Cófreces, Noa, Nistal-Villán, Estanislao, Veiga, Esteban, Vázquez, Jesús, Pasqual, Giulia, Sánchez-Madrid, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600134/
https://www.ncbi.nlm.nih.gov/pubmed/37880206
http://dx.doi.org/10.1038/s41467-023-42480-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600134/
https://www.ncbi.nlm.nih.gov/pubmed/37880206
http://dx.doi.org/10.1038/s41467-023-42480-3

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