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Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication

Adolescent cannabis use increases the risk for cognitive impairments and psychiatric disorders. Cannabinoid receptor type 1 (Cnr1) is expressed not only in neurons and astrocytes, but also in microglia, which shape synaptic connections during adolescence. However, the role of microglia in mediating...

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Detalles Bibliográficos
Autores principales: Hasegawa, Yuto, Kim, Juhyun, Ursini, Gianluca, Jouroukhin, Yan, Zhu, Xiaolei, Miyahara, Yu, Xiong, Feiyi, Madireddy, Samskruthi, Obayashi, Mizuho, Lutz, Beat, Sawa, Akira, Brown, Solange P., Pletnikov, Mikhail V., Kamiya, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600150/
https://www.ncbi.nlm.nih.gov/pubmed/37880248
http://dx.doi.org/10.1038/s41467-023-42276-5