New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies

[Image: see text] The antibiotic resistance problems constitute a considerable threat to human health worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an imperative requirement. From this view, new thiophenyl-pyrazolyl-thiazole hybrids 3–10 were synthesized and...

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Detalles Bibliográficos
Autores principales: Dawood, Dina H., Sayed, Manal M., Tohamy, Sally T. K., Nossier, Eman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600881/
https://www.ncbi.nlm.nih.gov/pubmed/37901585
http://dx.doi.org/10.1021/acsomega.3c04736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600881/
https://www.ncbi.nlm.nih.gov/pubmed/37901585
http://dx.doi.org/10.1021/acsomega.3c04736

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