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New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies

[Image: see text] The antibiotic resistance problems constitute a considerable threat to human health worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an imperative requirement. From this view, new thiophenyl-pyrazolyl-thiazole hybrids 3–10 were synthesized and...

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Detalles Bibliográficos
Autores principales:	Dawood, Dina H., Sayed, Manal M., Tohamy, Sally T. K., Nossier, Eman S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600881/ https://www.ncbi.nlm.nih.gov/pubmed/37901585 http://dx.doi.org/10.1021/acsomega.3c04736

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