Dehydroepiandrosterone Sulfate (DHEAS) Is an Endogenous Kv7 Channel Modulator That Reduces Kv7/M-Current Suppression and Inflammatory Pain

Neuronal Kv7 voltage-gated potassium channels generate the M-current and regulate neuronal excitability. Here, we report that dehydroepiandrosterone sulfate (DHEAS) is an endogenous Kv7 channel modulator that attenuates Gq-coupled receptor-induced M-current suppression. DHEAS reduced muscarinic agon...

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Detalles Bibliográficos
Autores principales: Alhassen, Lamees, Alhassen, Wedad, Wong, Cindy, Sun, Yuxuan, Xia, Zelin, Civelli, Olivier, Hoshi, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601364/
https://www.ncbi.nlm.nih.gov/pubmed/37648450
http://dx.doi.org/10.1523/JNEUROSCI.2307-22.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601364/
https://www.ncbi.nlm.nih.gov/pubmed/37648450
http://dx.doi.org/10.1523/JNEUROSCI.2307-22.2023

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