Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report
We present the case of a 64-year-old female with stage IV gastric adenocarcinoma, pulmonary, and abdominal wall metastases, and no history of cardiovascular disease. In palliative care, she received systemic cytotoxic treatment with fluorouracil, leucovorin, oxaliplatin, and docetaxel protocol, whic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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S. Karger AG
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601726/ https://www.ncbi.nlm.nih.gov/pubmed/37900810 http://dx.doi.org/10.1159/000531389 |
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author | Osorio-Toro, Luis Miguel Bonilla-Bonilla, Diana Marcela Escobar-Dávila, Santiago Leandro Quintana-Ospina, Jhon Herney Melo-Burbano, Luis Álvaro Benitez-Escobar, Edith Norela Galindes-Casanova, Duván Arley Daza- Arana, Jorge Enrique Rivas-Tafurt, Giovanna Patricia |
author_facet | Osorio-Toro, Luis Miguel Bonilla-Bonilla, Diana Marcela Escobar-Dávila, Santiago Leandro Quintana-Ospina, Jhon Herney Melo-Burbano, Luis Álvaro Benitez-Escobar, Edith Norela Galindes-Casanova, Duván Arley Daza- Arana, Jorge Enrique Rivas-Tafurt, Giovanna Patricia |
author_sort | Osorio-Toro, Luis Miguel |
collection | PubMed |
description | We present the case of a 64-year-old female with stage IV gastric adenocarcinoma, pulmonary, and abdominal wall metastases, and no history of cardiovascular disease. In palliative care, she received systemic cytotoxic treatment with fluorouracil, leucovorin, oxaliplatin, and docetaxel protocol, which was well tolerated over five cycles. During cycle 6, she presented with cardiovascular symptoms with hemodynamic consequences while receiving oxaliplatin injection without docetaxel or 5-fluorouracil. She was transferred to the emergency department and then to the intensive care unit. She developed no complications during the hospital stay and was discharged after 10 days with preserved systolic function and no structural changes at the myocardial level. The electrocardiogram, echocardiogram, cardiac catheterization, and magnetic resonance imaging findings indicated an oxaliplatin-associated Takotsubo syndrome. The immunochemistry analysis showed PD-L1 expression level TPS: 40% and the foundation one genomic profiling revealed high mutation load, microsatellite instability, and HER2 not found. The patient is currently asymptomatic and on pembrolizumab monotherapy with good tolerance and partial treatment response. |
format | Online Article Text |
id | pubmed-10601726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-106017262023-10-27 Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report Osorio-Toro, Luis Miguel Bonilla-Bonilla, Diana Marcela Escobar-Dávila, Santiago Leandro Quintana-Ospina, Jhon Herney Melo-Burbano, Luis Álvaro Benitez-Escobar, Edith Norela Galindes-Casanova, Duván Arley Daza- Arana, Jorge Enrique Rivas-Tafurt, Giovanna Patricia Case Rep Oncol Case Report We present the case of a 64-year-old female with stage IV gastric adenocarcinoma, pulmonary, and abdominal wall metastases, and no history of cardiovascular disease. In palliative care, she received systemic cytotoxic treatment with fluorouracil, leucovorin, oxaliplatin, and docetaxel protocol, which was well tolerated over five cycles. During cycle 6, she presented with cardiovascular symptoms with hemodynamic consequences while receiving oxaliplatin injection without docetaxel or 5-fluorouracil. She was transferred to the emergency department and then to the intensive care unit. She developed no complications during the hospital stay and was discharged after 10 days with preserved systolic function and no structural changes at the myocardial level. The electrocardiogram, echocardiogram, cardiac catheterization, and magnetic resonance imaging findings indicated an oxaliplatin-associated Takotsubo syndrome. The immunochemistry analysis showed PD-L1 expression level TPS: 40% and the foundation one genomic profiling revealed high mutation load, microsatellite instability, and HER2 not found. The patient is currently asymptomatic and on pembrolizumab monotherapy with good tolerance and partial treatment response. S. Karger AG 2023-08-14 /pmc/articles/PMC10601726/ /pubmed/37900810 http://dx.doi.org/10.1159/000531389 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Osorio-Toro, Luis Miguel Bonilla-Bonilla, Diana Marcela Escobar-Dávila, Santiago Leandro Quintana-Ospina, Jhon Herney Melo-Burbano, Luis Álvaro Benitez-Escobar, Edith Norela Galindes-Casanova, Duván Arley Daza- Arana, Jorge Enrique Rivas-Tafurt, Giovanna Patricia Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report |
title | Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report |
title_full | Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report |
title_fullStr | Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report |
title_full_unstemmed | Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report |
title_short | Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report |
title_sort | oxaliplatin-associated takotsubo cardiomyopathy in a patient with metastatic gastric cancer: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601726/ https://www.ncbi.nlm.nih.gov/pubmed/37900810 http://dx.doi.org/10.1159/000531389 |
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