Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina

The crumbs cell polarity complex plays a crucial role in apical–basal epithelial polarity, cellular adhesion, and morphogenesis. Homozygous variants in human CRB1 result in autosomal recessive Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP), with no established genotype–phenotype corr...

Descripción completa

Detalles Bibliográficos
Autores principales: Owen, Nicholas, Toms, Maria, Tian, Yuan, Toualbi, Lyes, Richardson, Rose, Young, Rodrigo, Tracey‐White, Dhani, Dhami, Pawan, Beck, Stephan, Moosajee, Mariya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601974/
https://www.ncbi.nlm.nih.gov/pubmed/36656098
http://dx.doi.org/10.1002/path.6056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601974/
https://www.ncbi.nlm.nih.gov/pubmed/36656098
http://dx.doi.org/10.1002/path.6056

Ejemplares similares