The common TMEM173 HAQ, AQ alleles rescue CD4 T cell death, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

STING activation induces lymphocyte cell death that is independent of type I IFNs. The in vivo significance and mechanism of STING-mediated cell death is unclear. Using STING knock-in mice, we found that lymphocytes from the HAQ, AQ, and Q293 mice are resistant to STING-mediated cell death ex vivo,...

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Detalles Bibliográficos
Autores principales: Aybar-Torres, Alexandra, Saldarriaga, Lennon A, Pham, Ann T., Emtiazjoo, Amir M., Sharma, Ashish K, Bryant, Andrew J., Jin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602033/
https://www.ncbi.nlm.nih.gov/pubmed/37886547
http://dx.doi.org/10.1101/2023.10.05.561109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602033/
https://www.ncbi.nlm.nih.gov/pubmed/37886547
http://dx.doi.org/10.1101/2023.10.05.561109

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